Model system for cell adhesion mediated by weak carbohydrate-carbohydrate interactions.
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ABSTRACT:
SUBMITTER: Lorenz B
PROVIDER: S-EPMC3288207 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Publications
Model system for cell adhesion mediated by weak carbohydrate-carbohydrate interactions.
Lorenz Bärbel B Álvarez de Cienfuegos Luis L Oelkers Marieelen M Kriemen Ella E Brand Christian C Stephan Milena M Sunnick Eva E Yüksel Deniz D Kalsani Venkateshwarlu V Kumar Krishna K Werz Daniel B DB Janshoff Andreas A
Journal of the American Chemical Society 20120210 7
The multivalent carbohydrate-carbohydrate interaction between membrane-anchored epitopes derived from the marine sponge Microciona prolifera has been explored by colloidal probe microscopy. An in situ coupling of sulfated and non-sulfated disaccharides to membrane-coated surfaces was employed to mimic native cell-cell contacts.The dynamic strength of the homomeric self-association was measured as a function of calcium ions and loading rate. A deterministic model was used to estimate the basic en ...[more]
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