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Weak Molecular Interactions in Clathrin-Mediated Endocytosis.

ABSTRACT: Clathrin-mediated endocytosis is a process by which specific molecules are internalized from the cell periphery for delivery to early endosomes. The key stages in this step-wise process, from the starting point of cargo recognition, to the later stage of assembly of the clathrin coat, are dependent on weak interactions between a large network of proteins. This review discusses the structural and functional data that have improved our knowledge and understanding of the main weak molecular interactions implicated in clathrin-mediated endocytosis, with a particular focus on the two key proteins: AP2 and clathrin.

SUBMITTER: Smith SM

PROVIDER: S-EPMC5694535 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Weak Molecular Interactions in Clathrin-Mediated Endocytosis.

Smith Sarah M SM Baker Michael M Halebian Mary M Smith Corinne J CJ

Frontiers in molecular biosciences 20171114

Clathrin-mediated endocytosis is a process by which specific molecules are internalized from the cell periphery for delivery to early endosomes. The key stages in this step-wise process, from the starting point of cargo recognition, to the later stage of assembly of the clathrin coat, are dependent on weak interactions between a large network of proteins. This review discusses the structural and functional data that have improved our knowledge and understanding of the main weak molecular interac ...[more]

PMID: 29184887

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