Ontology highlight
ABSTRACT:
SUBMITTER: Saha S
PROVIDER: S-EPMC3288401 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Saha Sougata S Wang Junling J Buckley Brian B Wang Qingqing Q Lilly Brenda B Chernov Mikhail M Kashina Anna A
Biochemical pharmacology 20120118 7
Posttranslational arginylation mediated by arginyltransferase (ATE1) is an emerging major regulator of embryogenesis and cell physiology. Impairments of ATE1 are implicated in congenital heart defects, obesity, cancer, and neurodegeneration making this enzyme an important therapeutic target, whose potential has been virtually unexplored. Here we report the development of a biochemical assay for identification of small molecule inhibitors of ATE1 and application of this assay to screen a library ...[more]