Small molecule inhibitors of cyclin-dependent kinase 9 for cancer therapy.
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ABSTRACT:
SUBMITTER: Alsfouk A
PROVIDER: S-EPMC7919902 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
Small molecule inhibitors of cyclin-dependent kinase 9 for cancer therapy.
Journal of enzyme inhibition and medicinal chemistry 20211201 1
Cyclin-dependent kinase 9 (CDK9) plays a vital role in transcription through regulation of short-lived anti-apoptotic genes required for cancer cell survival. Therefore, targeting CDK9 with small molecule inhibitors has emerged as a potential cancer therapy. This article reviews the most recent CDK9 patent literature (2012-2020) related to small molecule inhibitors in cancer along with their selectivity profile and biological results in preclinical studies. ...[more]
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