Ontology highlight
ABSTRACT:
SUBMITTER: Johansen CT
PROVIDER: S-EPMC3288444 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Johansen Christopher T CT Wang Jian J McIntyre Adam D AD Martins Rebecca A RA Ban Matthew R MR Lanktree Matthew B MB Huff Murray W MW Péterfy Miklós M Mehrabian Margarete M Lusis Aldons J AJ Kathiresan Sekar S Anand Sonia S SS Yusuf Salim S Lee Ann-Hwee AH Glimcher Laurie H LH Cao Henian H Hegele Robert A RA
Circulation. Cardiovascular genetics 20111201 1
<h4>Background</h4>Rare variant accumulation studies can implicate genes in disease susceptibility when a significant burden is observed in patients versus control subjects. Such analyses might be particularly useful for candidate genes that are selected based on experiments other than genome-wide association studies (GWAS). We sought to determine whether rare variants in non-GWAS candidate genes identified from mouse models and human mendelian syndromes of hypertriglyceridemia (HTG) accumulate ...[more]