Ontology highlight
ABSTRACT:
SUBMITTER: Sethi D
PROVIDER: S-EPMC3288683 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Sethi Dalip D Chen Chang-Po CP Jing Rui-Yan RY Thakur Mathew L ML Wickstrom Eric E
Bioconjugate chemistry 20120125 2
Monoamine oxidases (MAO) catalyze the oxidative deamination of many biogenic amines and are integral proteins found in the mitochondrial outer membrane. Changes in MAO-A levels are associated with depression, trait aggression, and addiction. Here we report the synthesis, characterization, and in vitro evaluation of novel fluorescent peptide-peptide nucleic acid (PNA) chimeras for MAOA mRNA imaging in live neuronal cells. The probes were designed to include MAOA-specific PNA dodecamers, separated ...[more]