On the estimation of T-wave alternans using the spectral fast fourier transform method.

ABSTRACT:

Background

T-wave alternans (TWA) has been associated with increased vulnerability to ventricular tachyarrhythmias and sudden cardiac death. However, both random (white) noise and (patho)physiologic processes (ie, premature ventricular contractions and heart and respiration rates) may hamper TWA estimation and therefore lessen its clinical utility for risk stratification.

Objective

To investigate the effect of random noise and certain (patho)physiologic processes on the estimation of TWA by using the fast Fourier transform method and to develop methods to overcome these potential sources of error.

Methods

We used a combination of human electrocardiogram data and computer simulations to assess the effects of a premature ventricular contraction and random and colored no

SUBMITTER: Armoundas AA 

PROVIDER: S-EPMC3288719 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature