Ontology highlight
ABSTRACT:
SUBMITTER: Weiss MS
PROVIDER: S-EPMC3288720 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Weiss Michael S MS Bernabé Beatriz Peñalver BP Shikanov Ariella A Bluver Dennis A DA Mui Michael D MD Shin Seungjin S Broadbelt Linda J LJ Shea Lonnie D LD
Biomaterials 20120215 13
The microenviroment contributes to directing mammary epithelial cell (MEC) development and the progression of breast cancer. Three-dimensional culture models have been used to support formation of structures that display varying degrees of disorganization that parallel the degree of cancer. Synthetic hydrogels were employed to investigate the mechanisms by which specific adhesion signals in the microenvironment directed development. Polyethylene glycol-based hydrogels supported 3D growth of MECs ...[more]