Ontology highlight
ABSTRACT:
SUBMITTER: Kirubakaran S
PROVIDER: S-EPMC3289519 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20120124 5
Cryptosporidium parasites are important waterborne pathogens of both humans and animals. The Cryptosporidium parvum and Cryptosporidium hominis genomes indicate that the only route to guanine nucleotides is via inosine 5'-monophosphate dehydrogenase (IMPDH). Thus the inhibition of the parasite IMPDH presents a potential strategy for treating Cryptosporidium infections. A selective benzimidazole-based inhibitor of C. parvum IMPDH (CpIMPDH) was previously identified in a high throughput screen. He ...[more]