Ontology highlight
ABSTRACT:
SUBMITTER: Lodola A
PROVIDER: S-EPMC3289653 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Lodola Alessio A Branduardi Davide D De Vivo Marco M Capoferri Luigi L Mor Marco M Piomelli Daniele D Cavalli Andrea A
PloS one 20120228 2
The N-terminal nucleophile (Ntn) hydrolases are a superfamily of enzymes specialized in the hydrolytic cleavage of amide bonds. Even though several members of this family are emerging as innovative drug targets for cancer, inflammation, and pain, the processes through which they catalyze amide hydrolysis remains poorly understood. In particular, the catalytic reactions of cysteine Ntn-hydrolases have never been investigated from a mechanistic point of view. In the present study, we used free ene ...[more]