Ontology highlight
ABSTRACT:
SUBMITTER: Shcheglovitov A
PROVIDER: S-EPMC3289959 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Shcheglovitov Aleksandr A Vitko Iuliia I Lazarenko Roman M RM Orestes Peihan P Todorovic Slobodan M SM Perez-Reyes Edward E
The Journal of general physiology 20120301 3
Here, we describe a new mechanism by which glutamate (Glu) and trace metals reciprocally modulate activity of the Ca(v)2.3 channel by profoundly shifting its voltage-dependent gating. We show that zinc and copper, at physiologically relevant concentrations, occupy an extracellular binding site on the surface of Ca(v)2.3 and hold the threshold for activation of these channels in a depolarized voltage range. Abolishing this binding by chelation or the substitution of key amino acid residues in IS1 ...[more]