Ontology highlight
ABSTRACT:
SUBMITTER: La Salle S
PROVIDER: S-EPMC3290669 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
La Salle Sophie S Palmer Kristina K O'Brien Marilyn M Schimenti John C JC Eppig John J Handel Mary Ann MA
Biology of reproduction 20120229 2
The N-ethyl-N-nitrosourea-induced repro42 mutation, identified by a forward genetics strategy, causes both male and female infertility, with no other apparent phenotypes. Positional cloning led to the discovery of a nonsense mutation in Spata22, a hitherto uncharacterized gene conserved among bony vertebrates. Expression of both transcript and protein is restricted predominantly to germ cells of both sexes. Germ cells of repro42 mutant mice express Spata22 transcript, but not SPATA22 protein. Ga ...[more]