Ontology highlight
ABSTRACT:
SUBMITTER: Petrillo C
PROVIDER: S-EPMC7546082 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Petrillo Cynthia C Barroca Vilma V Ribeiro Jonathan J Lailler Nathalie N Livera Gabriel G Keeney Scott S Martini Emmanuelle E Jain Devanshi D
Chromosoma 20200510 2
Recombination is crucial for chromosome pairing and segregation during meiosis. SPATA22, along with its direct binding partner and functional collaborator, MEIOB, is essential for the proper repair of double-strand breaks (DSBs) during meiotic recombination. Here, we describe a novel point-mutated allele (shani) of mouse Spata22 that we isolated in a forward genetic screen. shani mutant mice phenocopy Spata22-null and Meiob-null mice: mutant cells appear to form DSBs and initiate meiotic recombi ...[more]