Ontology highlight
ABSTRACT:
SUBMITTER: Jin L
PROVIDER: S-EPMC3292188 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Jin Lingyan L Pahuja Kanika Bajaj KB Wickliffe Katherine E KE Gorur Amita A Baumgärtel Christine C Schekman Randy R Rape Michael M
Nature 20120222 7386
Packaging of proteins from the endoplasmic reticulum into COPII vesicles is essential for secretion. In cells, most COPII vesicles are approximately 60-80 nm in diameter, yet some must increase their size to accommodate 300-400 nm procollagen fibres or chylomicrons. Impaired COPII function results in collagen deposition defects, cranio-lenticulo-sutural dysplasia, or chylomicron retention disease, but mechanisms to enlarge COPII coats have remained elusive. Here, we identified the ubiquitin liga ...[more]