Ontology highlight
ABSTRACT:
SUBMITTER: Thompson JW
PROVIDER: S-EPMC3293540 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Thompson Joel W JW Salahudeen Ameen A AA Chollangi Srinivas S Ruiz Julio C JC Brautigam Chad A CA Makris Thomas M TM Lipscomb John D JD Tomchick Diana R DR Bruick Richard K RK
The Journal of biological chemistry 20120117 10
Mammalian cells maintain iron homeostasis by sensing changes in bioavailable iron levels and promoting adaptive responses. FBXL5 is a subunit of an E3 ubiquitin ligase complex that mediates the stability of iron regulatory protein 2, an important posttranscriptional regulator of several genes involved in iron metabolism. The stability of FBXL5 is regulated in an iron- and oxygen-responsive manner, contingent upon the presence of its N-terminal domain. Here we present the atomic structure of the ...[more]