Ontology highlight
ABSTRACT:
SUBMITTER: Kim SD
PROVIDER: S-EPMC3372856 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Kim Sun-Don SD Liu Jia Lie JL Roscioli Tony T Buckley Michael F MF Yagnik Garima G Boyadjiev Simeon A SA Kim Jinoh J
FEBS letters 20120420 10
Fibroblast growth factor receptors (FGFRs) play critical roles in craniofacial and skeletal development via multiple signaling pathways including MAPK, PI3K/AKT, and PLC-?. FGFR-mediated signaling is modulated by several regulators. Proteins with leucine-rich repeat (LRR) and/or immunoglobulin (IG) superfamily domains have been suggested to interact with FGFRs. In addition, fibronectin leucine-rich repeat transmembrane protein 3 (FLRT3) has been shown to modulate the FGFR-mediated signaling via ...[more]