Ontology highlight
ABSTRACT:
SUBMITTER: Chen C
PROVIDER: S-EPMC3293545 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Chen Chen C Gorlatova Natalia N Herzberg Osnat O
The Journal of biological chemistry 20120112 10
We show that changes in the nucleotide sequence alter the DNA conformation in the crystal structures of p63 DNA-binding domain (p63DBD) bound to its response element. The conformation of a 22-bp canonical response element containing an AT spacer between the two half-sites is unaltered compared with that containing a TA spacer, exhibiting superhelical trajectory. In contrast, a GC spacers abolishes the DNA superhelical trajectory and exhibits less bent DNA, suggesting that increased GC content ac ...[more]