Ontology highlight
ABSTRACT:
SUBMITTER: Larochelle A
PROVIDER: S-EPMC3293639 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Larochelle Andre A Gillette Jennifer M JM Desmond Ronan R Ichwan Brian B Cantilena Amy A Cerf Alexandra A Barrett A John AJ Wayne Alan S AS Lippincott-Schwartz Jennifer J Dunbar Cynthia E CE
Blood 20120106 8
Manipulation of hematopoietic stem/progenitor cells (HSPCs) ex vivo is of clinical importance for stem cell expansion and gene therapy applications. However, most cultured HSPCs are actively cycling, and show a homing and engraftment defect compared with the predominantly quiescent noncultured HSPCs. We previously showed that HSPCs make contact with osteoblasts in vitro via a polarized membrane domain enriched in adhesion molecules such as tetraspanins. Here we show that increased cell cycling d ...[more]