Ontology highlight
ABSTRACT:
SUBMITTER: Takagaki S
PROVIDER: S-EPMC6509332 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Takagaki Soichiro S Yamashita Rieko R Hashimoto Noriyoshi N Sugihara Kazushi K Kanari Kanako K Tabata Keisuke K Nishie Toshikazu T Oka Shogo S Miyanishi Masanori M Naruse Chie C Asano Masahide M
Scientific reports 20190509 1
The role of carbohydrate chains in leukocyte migration to inflamed sites during inflammation and trafficking to the lymph nodes under physiological conditions has been extensively characterized. Here, we report that carbohydrate chains also mediate the homing and engraftment of hematopoietic stem/progenitor cells (HSPCs) to the bone marrow (BM). In particular, we found that transplanted BM cells deficient in β-1,4-galactosyltransferase-1 (β4GalT-1) could not support survival in mice exposed to a ...[more]