Ontology highlight
ABSTRACT:
SUBMITTER: Ru Z
PROVIDER: S-EPMC3293898 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Ru Zhitao Z Xiao Wenjun W Pajot Anthony A Kou Zhihua Z Sun Shihui S Maillere Bernard B Zhao Guangyu G Ojcius David M DM Lone Yu-Chun YC Zhou Yusen Y
PloS one 20120305 3
A new homozygous humanized transgenic mouse strain, HLA-A2.1(+/+)HLA-DP4(+/+) hCD4(+/+)mCD4(-/-)IAβ(-/-)β2m(-/-) (HLA-A2/DP4), was obtained by crossing the previously characterized HLA-A2(+/+)β2m(-/-) (A2) mouse and our previously created HLA-DP4(+/+) hCD4(+/+)mCD4(-/-)IAβ(-/-) (DP4) mouse. We confirmed that the transgenes (HLA-A2, HLA-DP4, hCD4) inherited from the parental A2 and DP4 mice are functional in the HLA-A2/DP4 mice. After immunizing HLA-A2/DP4 mice with a hepatitis B DNA vaccine, hep ...[more]