Partial excision of blaKPC from Tn4401 in carbapenem-resistant Klebsiella pneumoniae.
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ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC3294926 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Publications
Partial excision of blaKPC from Tn4401 in carbapenem-resistant Klebsiella pneumoniae.
Chen Liang L Chavda Kalyan D KD Mediavilla José R JR Jacobs Michael R MR Levi Michael H MH Bonomo Robert A RA Kreiswirth Barry N BN
Antimicrobial agents and chemotherapy 20111227 3
We describe a novel Tn4401 variant (Tn4401d) in epidemic Klebsiella pneumoniae clone ST258, from which a partial bla(KPC) fragment has been excised along with ISKpn7 and a partial tnpA fragment. Nested-PCR experiments confirmed that this region can be removed from distinct Tn4401 isoforms in both K. pneumoniae and Escherichia coli. This study highlights that the region surrounding bla(KPC) is undergoing recombination and that Tn4401 itself is heterogeneous and highly plastic. ...[more]
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