Cell-associated hemolysis induced by Helicobacter pylori is mediated by phospholipases with mitogen-activated protein kinase-activating properties.
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ABSTRACT:
SUBMITTER: Sitaraman R
PROVIDER: S-EPMC3295145 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Publications
Cell-associated hemolysis induced by Helicobacter pylori is mediated by phospholipases with mitogen-activated protein kinase-activating properties.
Sitaraman Ramakrishnan R Israel Dawn A DA Romero-Gallo Judith J Peek Richard M RM
Journal of clinical microbiology 20120111 3
Pathogenic Helicobacter pylori strains can selectively activate epithelial mitogen-activated protein kinase (MAPK) signaling pathways linked with disease. We now demonstrate that H. pylori-induced hemolysis is strain specific and is mediated by phospholipases PldA1 and PldD. Inactivation of PldD inhibited activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2), indicating that H. pylori hemolytic phospholipases also harbor MAPK-activating properties. ...[more]
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