Ontology highlight
ABSTRACT:
SUBMITTER: Remorino A
PROVIDER: S-EPMC3295544 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Remorino Amanda A Korendovych Ivan V IV Wu Yibing Y DeGrado William F WF Hochstrasser Robin M RM
Science (New York, N.Y.) 20110601 6034
Two-dimensional (2D) vibrational echo spectroscopy has previously been applied to structural determination of small peptides. Here we extend the technique to a more complex, biologically important system: the homodimeric transmembrane dimer from the α chain of the integrin α(IIb)β(3). We prepared micelle suspensions of the pair of 30-residue chains that span the membrane in the native structure, with varying levels of heavy ((13)C=(18)O) isotopes substituted in the backbone of the central 10th t ...[more]