Ontology highlight
ABSTRACT:
SUBMITTER: Russell AJ
PROVIDER: S-EPMC3296825 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Russell Alan J AJ Hartman James J JJ Hinken Aaron C AC Muci Alexander R AR Kawas Raja R Driscoll Lena L Godinez Guillermo G Lee Kenneth H KH Marquez David D Browne William F WF Chen Michael M MM Clarke David D Collibee Scott E SE Garard Marc M Hansen Richard R Jia Zhiheng Z Lu Pu-Ping PP Rodriguez Hector H Saikali Khalil G KG Schaletzky Julia J Vijayakumar Vipin V Albertus Daniel L DL Claflin Dennis R DR Morgans David J DJ Morgan Bradley P BP Malik Fady I FI
Nature medicine 20120219 3
Limited neural input results in muscle weakness in neuromuscular disease because of a reduction in the density of muscle innervation, the rate of neuromuscular junction activation or the efficiency of synaptic transmission. We developed a small-molecule fast-skeletal-troponin activator, CK-2017357, as a means to increase muscle strength by amplifying the response of muscle when neural input is otherwise diminished secondary to neuromuscular disease. Binding selectively to the fast-skeletal-tropo ...[more]