Ontology highlight
ABSTRACT:
SUBMITTER: Hwee DT
PROVIDER: S-EPMC4013064 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Hwee Darren T DT Kennedy Adam A Ryans Julie J Russell Alan J AJ Jia Zhiheng Z Hinken Aaron C AC Morgans David J DJ Malik Fady I FI Jasper Jeffrey R JR
PloS one 20140507 5
Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease characterized by progressive motor neuron loss resulting in muscle atrophy, declining muscle function, and eventual paralysis. Patients typically die from respiratory failure 3 to 5 years from the onset of symptoms. Tirasemtiv is a fast skeletal troponin activator that sensitizes the sarcomere to calcium; this mechanism of action amplifies the response of muscle to neuromuscular input producing greater force when nerve input is reduce ...[more]