Association between gastric cancer and -1993 polymorphism of TBX21 gene.

ABSTRACT:

Aim

To investigate the association between the polymorphism of TBX21 gene and the risk of gastric cancer in a Chinese population.

Methods

The -1993 polymorphism located in TBX21 gene promoter region was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The risk between TBX21 gene genotype and gastric cancer was determined by multivariate logistic regression analysis in 220 gastric cancer patients and 262 cancer-free controls matched by age, sex and ethnicity.

Results

Compared with the TBX21 -1993TT genotype, the -1993CC genotype exhibited a significantly elevated risk for gastric cancer [Odds ratio (OR) = 3.42, 95% confidence interval (CI): 1.41-8.31]. The relationship between the -1993 polymorphic genotype and the inv

SUBMITTER: Zhang LH 

PROVIDER: S-EPMC3296987 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature