Association between the XPG gene rs2094258 polymorphism and risk of gastric cancer.

ABSTRACT:

Background

Xeroderma pigmentosum group G (XPG) plays an important role in maintaining the stability and integrity of genomic DNA. Previous studies demonstrate some XPG gene polymorphisms are associated with susceptibility to gastric cancer (GC).

Methods

The association between XPG rs2094258 polymorphism and GC risk was investigated first by a hospital-based case-control study involving 386 patients and 439 controls and then by a meta-analysis. The polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLR).

Results

Xeroderma pigmentosum group G rs2094258 polymorphism was associated with an increased risk of GC in a Chinese population. The meta-analysis did not reveal any significant difference in the overall population.

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC6816837 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature