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Four eremophilane sesquiterpenes from the mangrove endophytic fungus Xylaria sp. BL321.

ABSTRACT: Three new eremophilane sesquiterpenes (1-3) were isolated from the mangrove endophytic fungus Xylaria sp. BL321 together with 07H239-A (4), a known analogue of the new compounds. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. Compound 4 showed activation activity on ?-glucosidase at 0.15 ?M (146%), and then, 4 gradually produced inhibitory activity on ?-glucosidase with increasing concentration, and the IC?? value is 6.54 ?M.

SUBMITTER: Song Y

PROVIDER: S-EPMC3297001 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Four eremophilane sesquiterpenes from the mangrove endophytic fungus Xylaria sp. BL321.

Song Yongxiang Y Wang Jiajian J Huang Hongbo H Ma Lin L Wang Jun J Gu Yucheng Y Liu Lan L Lin Yongcheng Y

Marine drugs 20120206 2

Three new eremophilane sesquiterpenes (1-3) were isolated from the mangrove endophytic fungus Xylaria sp. BL321 together with 07H239-A (4), a known analogue of the new compounds. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. Compound 4 showed activation activity on α-glucosidase at 0.15 μM (146%), and then, 4 gradually produced inhibitory activity on α-glucosidase with increasing concentration, and the IC₅₀ value is 6.54 μM. ...[more]

PMID: 22412805

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