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2,6-Bis[(S)-1-phenyl-eth-yl]-1H,5H-pyrrolo-[3,4-f]isoindole-1,3,5,7(2H,6H)-tetrone.

ABSTRACT: In the title compound, C(26)H(20)N(2)O(4), the central isoindole core is almost planar (r.m.s. deviation = 0.043 Å). The phenyl rings lie to either side of the plane [dihedral angles = 88.64 (5) and 67.74 (6)°] and the dihedral angle between the phenyl rings is 63.39 (7)°. In the crystal, mol-ecules are linked by C-H⋯O inter-actions; notably, one carbonyl O atom accepts three such bonds.

SUBMITTER: Abdel-Aziz AA

PROVIDER: S-EPMC3297950 | biostudies-literature |

REPOSITORIES: biostudies-literature

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3,3'-(1,3,5,7-Tetra-oxo-2,3,6,7-tetra-hydro-1H,5H-pyrrolo[3,4-f]isoindole-2,6-di-yl)dipropanoic acid N,N-dimethyl-formamide disolvate.

Project description:In the title compound, C(16)H(12)N(2)O(8)·2C(3)H(7)NO, the complete tricyclic compound is generated by a crystallographic centre of symmetry. In the crystal, the tricycle is linked to two adjacent N,N-dimethyl-formamide solvent mol-ecules by O-H?O hydrogen bonds.

| S-EPMC2972018 | biostudies-literature

3,7-Dihydr-oxy-3,7-diphenyl-2H,6H-pyrrolo[3,4-f]isoindole-1,5(3H,7H)-dione methanol disolvate.

Project description:The asymmetric unit of the title compound, C(22)H(16)N(2)O(4)·2CH(4)O, contains one half-mol-ecule and a methanol solvent mol-ecule. The aromatic ring is oriented at a dihedral angle of 82.91 (3)° with respect to the planar indole ring systems. In the crystal structure, inter-molecular O-H⋯O and N-H⋯O hydrogen bonds link the mol-ecules into chains along the b axis.

| S-EPMC2959835 | biostudies-literature

2,2'-(1,3,5,7-Tetra-oxo-1,2,3,5,6,7-hexa-hydro-pyrrolo[3,4-f]isoindole-2,6-di-yl)diacetic acid N,N-dimethyl-formamide disolvate.

Project description:The asymmetric unit of the title compound, C(14)H(8)N(2)O(8)·2C(3)H(7)NO or L·2DMF (DMF = N,N-dimethyl-formamide), contains one half of the centrosymmetric mol-ecule L and one solvent mol-ecule, which is disordered between two orientations in a 0.555?(4):0.445?(4) ratio. Inter-molecular O-H?O hydrogen bonds link one L and two DMF mol-ecules into a centrosymmetric hydrogen-bonded cluster. The crystal packing is further stabilized by weak inter-molecular C-H?O hydrogen bonds.

| S-EPMC2970400 | biostudies-literature

2,5-Dihexyl-3,6-diphenyl-pyrrolo-[3,4-c]pyrrole-1,4(2H,5H)-dione.

Project description:The asymmetric unit of the title compound, C(30)H(36)N(2)O(2), contains one half-mol-ecule, the other half being generated by a crystallographic inversion centre. The crystal structure is devoid of any classical hydrogen bonds however, non-classical C-H?O inter-actions link the mol-ecules into chains propagating in [001] and a C-H?? inter-action leads to the formation of a two-dimensional network in (011).

| S-EPMC3006905 | biostudies-other

1-Ethyl-1H,6H-pyrrolo[2,3-c]azepine-4,8(5H,7H)-dione.

Project description:The title compound, C(10)H(12)N(2)O(2), was synthesized by cyclization of 3-(1-ethyl-pyrrole-2-carboxamido)propanoic acid in the presence of polyphospho-ric acid and diphospho-rus pentoxide. In the crystal structure, adjacent mol-ecules are linked by N-H?O hydrogen bonds, forming chains extending along the b axis.

| S-EPMC2977308 | biostudies-literature

Crystal structure of 2,6-di-benzyl-pyrrolo-[3,4-f]iso-indole-1,3,5,7(2H,6H)-tetra-thione.

Project description:The title compound, C24H16N2S4, consists of a central pyromellitic di-imide substituted with an S atom and terminal benzyl groups. The mol-ecule lies on a crystallographic inversion centre so that the asymmetric unit contains half of the mol-ecule. The mol-ecule was prepared by thio-nation of N,N'-di-benzyl-pyromellitic di-imide with Lawesson's reagent and has an S-shaped conformation similar to other compounds of this type. The phenyl groups are tilted by 72.69 (8)° with respect to the plane of the central arene ring. In the crystal, mol-ecules are connected by C-H⋯π inter-actions and weak short S⋯S contacts, forming supra-molecular layers extending paralled to the ab plane. The crystal studied was found to be non-merohedrally twinned, with the minor component being 0.113 (3).

| S-EPMC5588585 | biostudies-literature

6-Benzyl-6,7-dihydro-5H-pyrrolo-[3,4-b]pyridine-5,7-dione.

Project description:In the title compound, C(14)H(10)N(2)O(2), the dihedral angle between the heterocyclic ring system and the phenyl ring is 45.8 (5)°. Weak inter-molecular C-H⋯N hydrogen bonding is present in the crystal structure.

| S-EPMC3247312 | biostudies-literature

6,6-Dimethyl-2H,5H,6H,7H-1,3-dithiolo[4,5-f][1,5,3]dithia-silepin-2-one.

Project description:In the structure of the title compound, C(7)H(10)OS(4)Si, the carbonyl O atom lies in the plane of the five-membered dithiole ring with a deviation of only 0.022?(2)?Å. The seven-membered ring adopts a chair conformation. The crystal packing is stabilized by S?O [3.096?(4)?Å] and S?S [3.620?(4)?Å] contacts, together with C-H?S inter-actions.

| S-EPMC3344068 | biostudies-literature

Bioresearch of New 1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones.

Project description:The subject of the work was the synthesis of new derivatives of1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione with potential analgesic and sedative activity. Eight compounds werereceived. The analgesic activity of the new compounds was confirmed in the "hot plate" test and in the "writhing" test. All tested imides 8-15 were more active in the "writhing" test than aspirin, and two of them, 9 and 11, were similar to morphine. In addition, all of the new imides inhibited the locomotor activity in mice to a statistically significant extent, and two of them also prolonged the duration of thiopental sleep.On the basis of the results obtained for the previously synthesized imides and the results presented in this paper, an attempt was madeto determine the relationship between thechemical structure of imides and their analgesic and sedativeproperties.

| S-EPMC7764601 | biostudies-literature

Methyl (9aR*,10S*,11R*,13aS*,13bS*)-9-oxo-6,7,9,9a,10,11-hexa-hydro-5H,13bH-11,13a-ep-oxy-pyrrolo-[2',1':3,4][1,4]diazepino[2,1-a]isoindole-10-carboxyl-ate.

Project description:The title compound, C(17)H(18)N(2)O(4), is the methyl ester of the adduct of intra-molecular Diels-Alder reaction between maleic anhydride and 1-(2-fur-yl)-2,3,4,5-tetra-hydro-1H-pyrrolo-[1,2-a][1,4]diazepine. The mol-ecule comprises a fused penta-cyclic system containing four five-membered rings (viz. pyrrole, 2-pyrrolidinone, tetra-hydro-furan and dihydro-furan) and one seven-membered ring (1,4-diazepane). The pyrrole ring is approximately planar (r.m.s. deviation = 0.003 Å) while the 2-pyrrolidinone, tetra-hydro-furan and dihydro-furan five-membered rings have the usual envelope conformations. The central seven-membered diazepane ring adopts a boat conformation. In the crystal, mol-ecules are bound by weak inter-molecular C-H⋯O hydrogen-bonding inter-actions into zigzag chains propagating in [010]. In the crystal packing, the chains are stacked along the a axis.

| S-EPMC3247590 | biostudies-literature

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