Ontology highlight
ABSTRACT:
SUBMITTER: Barascu A
PROVIDER: S-EPMC3297999 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
The EMBO journal 20120113 5
We report crosstalk between three senescence-inducing conditions, DNA damage response (DDR) defects, oxidative stress (OS) and nuclear shape alterations. The recessive autosomal genetic disorder Ataxia telangiectasia (A-T) is associated with DDR defects, endogenous OS and premature ageing. Here, we find frequent nuclear shape alterations in A-T cells, as well as accumulation of the key nuclear architecture component lamin B1. Lamin B1 overexpression is sufficient to induce nuclear shape alterati ...[more]