Ontology highlight
ABSTRACT:
SUBMITTER: Lee Y
PROVIDER: S-EPMC3298000 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Lee Youngsoo Y Shull Erin R P ER Frappart Pierre-Olivier PO Katyal Sachin S Enriquez-Rios Vanessa V Zhao Jingfeng J Russell Helen R HR Brown Eric J EJ McKinnon Peter J PJ
The EMBO journal 20120120 5
The ATR (ATM (ataxia telangiectasia mutated) and rad3-related) checkpoint kinase is considered critical for signalling DNA replication stress and its dysfunction can lead to the neurodevelopmental disorder, ATR-Seckel syndrome. To understand how ATR functions during neurogenesis, we conditionally deleted Atr broadly throughout the murine nervous system, or in a restricted manner in the dorsal telencephalon. Unexpectedly, in both scenarios, Atr loss impacted neurogenesis relatively late during ne ...[more]