Ontology highlight
ABSTRACT:
SUBMITTER: Cara L
PROVIDER: S-EPMC4705472 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Cara Lukas L Baitemirova Medina M Follis Jack J Larios-Sanz Maia M Ribes-Zamora Albert A
Scientific reports 20160108
ATM and ATR are cellular kinases with a well-characterized role in the DNA-damage response. Although the complete set of ATM/ATR targets is unknown, they often contain clusters of S/TQ motifs that constitute an SCD domain. In this study, we identified putative ATM/ATR targets that have a conserved SCD domain across vertebrates. Using this approach, we have identified novel putative ATM/ATR targets in pathways known to be under direct control of these kinases. Our analysis has also unveiled signi ...[more]