Ontology highlight
ABSTRACT:
SUBMITTER: Embade N
PROVIDER: S-EPMC3298572 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Embade Nieves N Fernández-Ramos David D Varela-Rey Marta M Beraza Naiara N Sini Marcella M Gutiérrez de Juan Virginia V Woodhoo Ashwin A Martínez-López Nuria N Rodríguez-Iruretagoyena Begoña B Bustamante Francisco Javier FJ de la Hoz Ana Belén AB Carracedo Arkaitz A Xirodimas Dimitris P DP Rodríguez Manuel S MS Lu Shelly C SC Mato José M JM Martínez-Chantar María L ML
Hepatology (Baltimore, Md.) 20120301 4
<h4>Unlabelled</h4>Hu antigen R (HuR) is a central RNA-binding protein regulating cell dedifferentiation, proliferation, and survival, which are well-established hallmarks of cancer. HuR is frequently overexpressed in tumors correlating with tumor malignancy, which is in line with a role for HuR in tumorigenesis. However, the precise mechanism leading to changes in HuR expression remains unclear. In the liver, HuR plays a crucial role in hepatocyte proliferation, differentiation, and transformat ...[more]