Ontology highlight
ABSTRACT:
SUBMITTER: Yan Z
PROVIDER: S-EPMC3298884 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Scientific reports 20120312
Highly efficient and specific biomolecular recognition requires both affinity and specificity. Previous quantitative descriptions of biomolecular recognition were mostly driven by improving the affinity prediction, but lack of quantification of specificity. We developed a novel method SPA (SPecificity and Affinity) based on our funneled energy landscape theory. The strategy is to simultaneously optimize the quantified specificity of the "native" protein-ligand complex discriminating against "non ...[more]