Unknown

Dataset Information

0

HIV-1 neutralization coverage is improved by combining monoclonal antibodies that target independent epitopes.

ABSTRACT: HIV-1 neutralizing monoclonal antibodies (MAbs) define key targets for vaccine development and are being considered for passive prevention of infection. We analyzed the interaction of MAbs to two independent epitopes on the viral envelope glycoprotein. Potently neutralizing MAbs to the CD4 binding site and V1V2 region displayed no in vitro cross-competition and displayed additive, though not synergistic, neutralization activity. Predicted neutralization coverage of a combination of two MAbs reached 97% on a 208-isolate panel.

SUBMITTER: Doria-Rose NA 

PROVIDER: S-EPMC3302320 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

HIV-1 neutralization coverage is improved by combining monoclonal antibodies that target independent epitopes.

Doria-Rose Nicole A NA   Louder Mark K MK   Yang Zhongjia Z   O'Dell Sijy S   Nason Martha M   Schmidt Stephen D SD   McKee Krisha K   Seaman Michael S MS   Bailer Robert T RT   Mascola John R JR  

Journal of virology 20120118 6

HIV-1 neutralizing monoclonal antibodies (MAbs) define key targets for vaccine development and are being considered for passive prevention of infection. We analyzed the interaction of MAbs to two independent epitopes on the viral envelope glycoprotein. Potently neutralizing MAbs to the CD4 binding site and V1V2 region displayed no in vitro cross-competition and displayed additive, though not synergistic, neutralization activity. Predicted neutralization coverage of a combination of two MAbs reac  ...[more]

Similar Datasets

Unknown Improving neutralization potency and breadth by combining broadly reactive HIV-1 antibodies targeting major neutralization epitopes.
| S-EPMC4325730 | biostudies-literature
Unknown Computational prediction of neutralization epitopes targeted by human anti-V3 HIV monoclonal antibodies.
| S-EPMC3934971 | biostudies-literature
Unknown Broad neutralization coverage of HIV by multiple highly potent antibodies.
| S-EPMC3393110 | biostudies-literature
Transcriptomics Broadly protective monoclonal antibodies against influenza B virus target highly conserved neuraminidase epitopes
2017-03-31 | GSE96091 | GEO
Unknown Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies.
| S-EPMC4534392 | biostudies-literature
Unknown Broader neutralization of CT-P27 against influenza A subtypes by combining two human monoclonal antibodies.
| S-EPMC7390384 | biostudies-literature
Unknown Neutralization of Zika virus by germline-like human monoclonal antibodies targeting cryptic epitopes on envelope domain III.
| S-EPMC5658772 | biostudies-literature
Unknown Broadly protective murine monoclonal antibodies against influenza B virus target highly conserved neuraminidase epitopes.
| S-EPMC5819343 | biostudies-literature
Unknown Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits.
| S-EPMC4866400 | biostudies-literature
Unknown Characterizing anti-HIV monoclonal antibodies and immune sera by defining the mechanism of neutralization.
| S-EPMC2630880 | biostudies-literature