Ontology highlight
ABSTRACT:
SUBMITTER: Doria-Rose NA
PROVIDER: S-EPMC3302320 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Doria-Rose Nicole A NA Louder Mark K MK Yang Zhongjia Z O'Dell Sijy S Nason Martha M Schmidt Stephen D SD McKee Krisha K Seaman Michael S MS Bailer Robert T RT Mascola John R JR
Journal of virology 20120118 6
HIV-1 neutralizing monoclonal antibodies (MAbs) define key targets for vaccine development and are being considered for passive prevention of infection. We analyzed the interaction of MAbs to two independent epitopes on the viral envelope glycoprotein. Potently neutralizing MAbs to the CD4 binding site and V1V2 region displayed no in vitro cross-competition and displayed additive, though not synergistic, neutralization activity. Predicted neutralization coverage of a combination of two MAbs reac ...[more]