Ontology highlight
ABSTRACT:
SUBMITTER: Robinson JE
PROVIDER: S-EPMC4866400 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Nature communications 20160510
Lassa fever is a severe multisystem disease that often has haemorrhagic manifestations. The epitopes of the Lassa virus (LASV) surface glycoproteins recognized by naturally infected human hosts have not been identified or characterized. Here we have cloned 113 human monoclonal antibodies (mAbs) specific for LASV glycoproteins from memory B cells of Lassa fever survivors from West Africa. One-half bind the GP2 fusion subunit, one-fourth recognize the GP1 receptor-binding subunit and the remaining ...[more]