Ontology highlight
ABSTRACT:
SUBMITTER: Wrammert J
PROVIDER: S-EPMC3302324 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Wrammert Jens J Onlamoon Nattawat N Akondy Rama S RS Perng Guey C GC Polsrila Korakot K Chandele Anmol A Kwissa Marcin M Pulendran Bali B Wilson Patrick C PC Wittawatmongkol Orasri O Yoksan Sutee S Angkasekwinai Nasikarn N Pattanapanyasat Kovit K Chokephaibulkit Kulkanya K Ahmed Rafi R
Journal of virology 20120111 6
Humoral immune responses are thought to play a major role in dengue virus-induced immunopathology; however, little is known about the plasmablasts producing these antibodies during an ongoing infection. Herein we present an analysis of plasmablast responses in patients with acute dengue virus infection. We found very potent plasmablast responses that often increased more than 1,000-fold over the baseline levels in healthy volunteers. In many patients, these responses made up as much 30% of the p ...[more]