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Dengue Virus-Specific Antibodies Enhance Brazilian Zika Virus Infection.

ABSTRACT: Anti-Flavivirus antibodies are highly cross-reactive and may facilitate Zika virus (ZIKV) infection through the antibody-dependent enhancement (ADE) mechanism. We demonstrate that dengue-specific antibodies enhance the infection of a primary Brazilian ZIKV isolate in a Fc?RII-expressing K562 cell line. In addition, we demonstrate that serum samples from dengue-immune pregnant women enhanced ZIKV infection. These findings highlight the need for epidemiological studies and animal models to further confirm the role of ADE in the development of congenital and neurological complications associated with ZIKV infections.

SUBMITTER: Castanha PMS

PROVIDER: S-EPMC5854042 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Dengue Virus-Specific Antibodies Enhance Brazilian Zika Virus Infection.

Castanha Priscila M S PMS Nascimento Eduardo J M EJM Braga Cynthia C Cordeiro Marli T MT de Carvalho Otávio V OV de Mendonça Leila R LR Azevedo Elisa A N EAN França Rafael F O RFO Dhalia Rafael R Marques Ernesto T A ETA

The Journal of infectious diseases 20170301 5

Anti-Flavivirus antibodies are highly cross-reactive and may facilitate Zika virus (ZIKV) infection through the antibody-dependent enhancement (ADE) mechanism. We demonstrate that dengue-specific antibodies enhance the infection of a primary Brazilian ZIKV isolate in a FcγRII-expressing K562 cell line. In addition, we demonstrate that serum samples from dengue-immune pregnant women enhanced ZIKV infection. These findings highlight the need for epidemiological studies and animal models to further ...[more]

PMID: 28039355

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