Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry.
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ABSTRACT:
SUBMITTER: Shimojima M
PROVIDER: S-EPMC3302412 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Publications
Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry.
Shimojima Masayuki M Ströher Ute U Ebihara Hideki H Feldmann Heinz H Kawaoka Yoshihiro Y
Journal of virology 20111207 4
Although O-mannosylated dystroglycan is a receptor for Lassa virus, a causative agent of Lassa fever, recent findings suggest the existence of an alternative receptor(s). Here we identified four molecules as receptors for Lassa virus: Axl and Tyro3, from the TAM family, and dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and liver and lymph node sinusoidal endothelial calcium-dependent lectin (LSECtin), from the C-type lectin family. These molecules enhan ...[more]
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