A noncanonical mu-1A-binding motif in the N terminus of HIV-1 Nef determines its ability to downregulate major histocompatibility complex class I in T lymphocytes.
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ABSTRACT:
SUBMITTER: Iijima S
PROVIDER: S-EPMC3302484 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Publications
A noncanonical mu-1A-binding motif in the N terminus of HIV-1 Nef determines its ability to downregulate major histocompatibility complex class I in T lymphocytes.
Iijima Sayuki S Lee Young-Jung YJ Ode Hirotaka H Arold Stefan T ST Kimura Nobuyuki N Yokoyama Masaru M Sato Hironori H Tanaka Yasuhito Y Strebel Klaus K Akari Hirofumi H
Journal of virology 20120201 7
Downregulation of major histocompatibility complex class I (MHC-I) by HIV-1 Nef protein is indispensable for evasion of protective immunity by HIV-1. Though it has been suggested that the N-terminal region of Nef contributes to the function by associating with a mu-1A subunit of adaptor protein 1, the structural basis of the interaction between Nef and mu-1A remains elusive. We found that a tripartite hydrophobic motif (Trp13/Val16/Met20) in the N terminus of Nef was required for the MHC-I downr ...[more]
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