Ontology highlight
ABSTRACT:
SUBMITTER: Gensel JC
PROVIDER: S-EPMC3302770 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
PloS one 20120313 3
Excess glutamate release and associated neurotoxicity contributes to cell death after spinal cord injury (SCI). Indeed, delayed administration of glutamate receptor antagonists after SCI in rodents improves tissue sparing and functional recovery. Despite their therapeutic potential, most glutamate receptor antagonists have detrimental side effects and have largely failed clinical trials. Topiramate is an AMPA-specific, glutamate receptor antagonists that is FDA-approved to treat CNS disorders. I ...[more]