Ontology highlight
ABSTRACT:
SUBMITTER: Fowler KD
PROVIDER: S-EPMC3302786 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Fowler Kevin D KD Kuchroo Vijay K VK Chakraborty Arup K AK
PloS one 20120313 3
The reason why IL-6 induces a pro-inflammatory response, while IL-10 induces an anti-inflammatory response, despite both cytokines activating the same transcription factor, STAT3, is not well understood. It is known that IL-6 induces a transient STAT3 signal and that IL-10 induces a sustained STAT3 signal due to the STAT3-induced inhibitor SOCS3's ability to bind to the IL-6R and not the IL-10R. We sought to develop a general transcriptional network that is capable of translating sustained signa ...[more]