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Halothane changes the domain structure of a binary lipid membrane.

ABSTRACT: X-ray and neutron diffraction studies of a binary lipid membrane demonstrate that halothane at physiological concentrations produces a pronounced redistribution of lipids between domains of different lipid types identified by different lamellar d-spacings and isotope composition. In contrast, dichlorohexafluorocyclobutane (F6), a halogenated nonanesthetic, does not produce such significant effects. These findings demonstrate a specific effect of inhalational anesthetics on mixing phase equilibria of a lipid mixture.

SUBMITTER: Weinrich M

PROVIDER: S-EPMC3302933 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

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Halothane changes the domain structure of a binary lipid membrane.

Weinrich Michael M Nanda Hirsh H Worcester David L DL Majkrzak Charles F CF Maranville Brian B BB Bezrukov Sergey M SM

Langmuir : the ACS journal of surfaces and colloids 20120228 10

X-ray and neutron diffraction studies of a binary lipid membrane demonstrate that halothane at physiological concentrations produces a pronounced redistribution of lipids between domains of different lipid types identified by different lamellar d-spacings and isotope composition. In contrast, dichlorohexafluorocyclobutane (F6), a halogenated nonanesthetic, does not produce such significant effects. These findings demonstrate a specific effect of inhalational anesthetics on mixing phase equilibri ...[more]

PMID: 22352350

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