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Halothane changes the domain structure of a binary lipid membrane.


ABSTRACT: X-ray and neutron diffraction studies of a binary lipid membrane demonstrate that halothane at physiological concentrations produces a pronounced redistribution of lipids between domains of different lipid types identified by different lamellar d-spacings and isotope composition. In contrast, dichlorohexafluorocyclobutane (F6), a halogenated nonanesthetic, does not produce such significant effects. These findings demonstrate a specific effect of inhalational anesthetics on mixing phase equilibria of a lipid mixture.

SUBMITTER: Weinrich M 

PROVIDER: S-EPMC3302933 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

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Halothane changes the domain structure of a binary lipid membrane.

Weinrich Michael M   Nanda Hirsh H   Worcester David L DL   Majkrzak Charles F CF   Maranville Brian B BB   Bezrukov Sergey M SM  

Langmuir : the ACS journal of surfaces and colloids 20120228 10


X-ray and neutron diffraction studies of a binary lipid membrane demonstrate that halothane at physiological concentrations produces a pronounced redistribution of lipids between domains of different lipid types identified by different lamellar d-spacings and isotope composition. In contrast, dichlorohexafluorocyclobutane (F6), a halogenated nonanesthetic, does not produce such significant effects. These findings demonstrate a specific effect of inhalational anesthetics on mixing phase equilibri  ...[more]

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