Ontology highlight
ABSTRACT:
SUBMITTER: Prod'homme V
PROVIDER: S-EPMC3303119 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Prod'homme Virginie V Tomasec Peter P Cunningham Charles C Lemberg Marius K MK Stanton Richard J RJ McSharry Brian P BP Wang Eddie C Y EC Cuff Simone S Martoglio Bruno B Davison Andrew J AJ Braud Véronique M VM Wilkinson Gavin W G GW
Journal of immunology (Baltimore, Md. : 1950) 20120215 6
Human CMV (HCMV)-encoded NK cell-evasion functions include an MHC class I homolog (UL18) with high affinity for the leukocyte inhibitory receptor-1 (CD85j, ILT2, or LILRB1) and a signal peptide (SP(UL40)) that acts by upregulating cell surface expression of HLA-E. Detailed characterization of SP(UL40) revealed that the N-terminal 14 aa residues bestowed TAP-independent upregulation of HLA-E, whereas C region sequences delayed processing of SP(UL40) by a signal peptide peptidase-type intramembran ...[more]