Ontology highlight
ABSTRACT:
SUBMITTER: Ellisdon AM
PROVIDER: S-EPMC3303126 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Ellisdon Andrew M AM Dimitrova Lyudmila L Hurt Ed E Stewart Murray M
Nature structural & molecular biology 20120219 3
The conserved TREX-2 transcription-export complex integrates transcription and processing of many actively transcribed nascent mRNAs with the recruitment of export factors at nuclear pores and also contributes to transcriptional memory and genomic stability. We report the crystal structure of the Sac3-Thp1-Sem1 segment of Saccharomyces cerevisiae TREX-2 that interfaces with the gene expression machinery. Sac3-Thp1-Sem1 forms a previously uncharacterized PCI-domain complex characterized by the ju ...[more]