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Tumour necrosis factor gene polymorphisms and migraine: a systematic review and meta-analysis.

ABSTRACT: Data on the association between TNF? and TNF? gene polymorphisms and migraine are conflicting.We performed a systematic review and meta-analysis of studies published until January 2011. We used data from published papers and as provided after contact with the authors. We calculated study specific odds ratios (OR) and 95% confidence intervals (CI) assuming additive, dominant, and recessive genetic models as well as pooled effect estimates.Among the ten studies identified, the best evidence is available for the TNF? -308G>A and TNF? 252A?>?G polymorphisms indicating no overall association with migraine. Subgroup analyses suggested that the A allele of the TNF? -308G?>?A variant more than doubles the risk for migraine among populations with a heterogeneous ethnic background, which was driven by associations for migraine without aura (additive model: pooled OR?=?2.87, 95% CI 1.86-4.43). Further, the risk for migraine with aura was increased among Asian populations (additive model: pooled OR?=?1.71, 95% CI 1.07-2.71). Both observed effects were stronger among females than males.Our results indicate no overall association between TNF? and TNF? gene variants and migraine. However, associations differed among specific populations. Our findings need to be treated with caution and further targeted research is warranted to evaluate population-specific effects including population stratification.

SUBMITTER: Schurks M

PROVIDER: S-EPMC3303222 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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Tumour necrosis factor gene polymorphisms and migraine: a systematic review and meta-analysis.

Schürks Markus M Rist Pamela M PM Zee Robert Yl RY Chasman Daniel I DI Kurth Tobias T

Cephalalgia : an international journal of headache 20111001 13

<h4>Background</h4>Data on the association between TNFα and TNFβ gene polymorphisms and migraine are conflicting.<h4>Methods</h4>We performed a systematic review and meta-analysis of studies published until January 2011. We used data from published papers and as provided after contact with the authors. We calculated study specific odds ratios (OR) and 95% confidence intervals (CI) assuming additive, dominant, and recessive genetic models as well as pooled effect estimates.<h4>Results</h4>Among t ...[more]

PMID: 22001640

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Project description:Inflammation is one of the early phases in the development of gastric cancer. Therefore, several studies have examined the association of polymorphisms in tumour-necrosis factor-A gene (TNF-A) with gastric cancer risk. This meta-analysis reviews and summarises published evidence for these associations. Searching several databases yielded 24 independent studies that reported on the associations between TNF-A polymorphisms and gastric cancer risk. We analysed available data for the most commonly investigated polymorphisms: TNF-A -308G>A (23 studies), TNF-A -238G>A (9 studies), and TNF-A -857C>T (5 studies). Summary odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated in the random-effects model using the DerSimonian-Laird method. Q-statistic and I(2)-statistic were calculated to examine heterogeneity, and funnel plots were plotted to examine small study effects. The overall ORs (95% CIs) for AG and AA genotypes vs GG genotype for TNF-A -308 were 1.09 (0.94-1.27) and 1.49 (1.11-1.99), respectively. For TNF-A -238, the corresponding ORs (95% CIs) were 1.05 (0.84-1.33) and 1.25 (0.30-5.26), respectively. The overall ORs (95% CIs) for CT and TT genotypes (vs CC) for TNF-A -857 were 1.06 (0.89-1.27) and 1.57 (0.91-2.70), respectively. The statistically significant association between TNF-A -308GG and gastric cancer was limited to western populations. This association showed little heterogeneity (I(2)=0) and remained consistently strong when analyses were limited to anatomic and histologic subtypes of gastric cancer, or limited to studies in which genotype frequencies were in Hardy-Weinberg equilibrium, or limited to larger studies. These same subgroup analyses did not change results associated with other polymorphisms. In conclusion, TNF-A -308AA genotype was associated with a statistically significant increased risk of gastric cancer, whereas other studied polymorphisms were not. The association between TNF-A -857TT genotype and gastric cancer was near significant, and may become significant if more studies are published.

Dataset Information

Tumour necrosis factor gene polymorphisms and migraine: a systematic review and meta-analysis.

Publications

Tumour necrosis factor gene polymorphisms and migraine: a systematic review and meta-analysis.

Similar Datasets

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