Ontology highlight
ABSTRACT:
SUBMITTER: Kilpatrick DC
PROVIDER: S-EPMC3303570 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Journal of biomedicine & biotechnology 20120228
Human L-ficolin (P35, ficolin-2) is synthesised in the liver and secreted into the bloodstream where it is one of the major pattern recognition molecules of plasma/serum. Like other ficolins, it consists of a collagen-like tail region linked to a fibrinogen-related globular head; a basic triplet subunit arises via a collagen-like triple helix, and this then forms higher multimers (typically a 12-mer, Mr 400K). Unlike other ficolins, it has a complex set of binding sites arranged within an intern ...[more]