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Roles of pro- and anti-inflammatory cytokines in the pathogenesis of SLE.

ABSTRACT: SLE is an autoimmune inflammatory disease in which various pro- and anti-inflammatory cytokines, including TGF-?, IL-10, BAFF, IL-6, IFN-?, IFN-?, IL-17, and IL-23, play crucial pathogenic roles. Virtually, all these cytokines can be generated by both innate and adaptive immune cells and exert different effects depending on specific local microenvironment. They can also interact with each other, forming a complex network to maintain delicate immune homeostasis. In this paper, we elaborate on the abnormal secretion and functions of these cytokines in SLE, analyze their potential pathogenic roles, and probe into the possibility of them being utilized as targets for therapy.

SUBMITTER: Su DL

PROVIDER: S-EPMC3303597 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Roles of pro- and anti-inflammatory cytokines in the pathogenesis of SLE.

Su Ding-Lei DL Lu Zhi-Min ZM Shen Min-Ning MN Li Xia X Sun Ling-Yun LY

Journal of biomedicine & biotechnology 20120215

SLE is an autoimmune inflammatory disease in which various pro- and anti-inflammatory cytokines, including TGF-β, IL-10, BAFF, IL-6, IFN-α, IFN-γ, IL-17, and IL-23, play crucial pathogenic roles. Virtually, all these cytokines can be generated by both innate and adaptive immune cells and exert different effects depending on specific local microenvironment. They can also interact with each other, forming a complex network to maintain delicate immune homeostasis. In this paper, we elaborate on the ...[more]

PMID: 22500087

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