Ontology highlight
ABSTRACT:
SUBMITTER: Cozy LM
PROVIDER: S-EPMC3303961 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Cozy Loralyn M LM Phillips Andrew M AM Calvo Rebecca A RA Bate Ashley R AR Hsueh Yi-Huang YH Bonneau Richard R Eichenberger Patrick P Kearns Daniel B DB
Molecular microbiology 20120222 6
Exponentially growing Bacillus subtilis cultures are epigenetically differentiated into two subpopulations in which cells are either ON or OFF for σ(d) -dependent gene expression: a pattern suggestive of bistability. The gene encoding σ(D) , sigD, is part of the 31-gene fla/che operon where its location at the 3' end, 25 kb away from the strong P(fla/che) promoter, determines its expression level relative to a threshold. Here we show that addition of a single extra copy of the slrA gene in the c ...[more]