Ontology highlight
ABSTRACT:
SUBMITTER: Ababneh QO
PROVIDER: S-EPMC4288673 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Ababneh Qutaiba O QO Herman Jennifer K JK
Journal of bacteriology 20141020 1
The nucleotide second messengers pppGpp and ppGpp [(p)ppGpp] are responsible for the global downregulation of transcription, translation, DNA replication, and growth rate that occurs during the stringent response. More recent studies suggest that (p)ppGpp is also an important effector in many nonstringent processes, including virulence, persister cell formation, and biofilm production. In Bacillus subtilis, (p)ppGpp production is primarily determined by the net activity of RelA, a bifunctional ( ...[more]